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What are the cardinal signs of congestive cardiac failure?A. In addition, Mdm2 can recruit the histone deacetylase HDAC1 [67]and the nuclear corepressor KAP1 [68], providing alternative ways by which Mdm2can repress the acetylation of either p53 or histones surrounding the p53 bindingsites. Predictive in vitro screening of environmental chemicals—theToxCast project. Abnormal clinical neu-rological manifestations that may be related tocerebral hypoperfusion have been observed in anumber of studies. She adds that there is a direct correlation between thespeed of mortality and the escalation of panic.

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Popowicz GM, Domling A, Holak TA (2011) The structure-based design of Mdm2/Mdmx-p53 inhibitors gets serious.

Poor prognosis wasassociated with positive nodal status, cervical squamous cell histology, and positivesurgical margins.

Interestingly,Mdm2 overexpression occurs more frequently in metastatic and recurrent tumorsthan it does in primary tumors [ 9 , 28].

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